Search results for " substitution test"

showing 4 items of 4 documents

Short telomere length is associated with impaired cognitive performance in European ancestry cohorts

2017

AbstractThe association between telomere length (TL) dynamics on cognitive performance over the life-course is not well understood. This study meta-analyses observational and causal associations between TL and six cognitive traits, with stratifications on APOE genotype, in a Mendelian Randomization (MR) framework. Twelve European cohorts (N=17 052; mean age=59.2±8.8 years) provided results for associations between qPCR-measured TL (T/S-ratio scale) and general cognitive function, mini-mental state exam (MMSE), processing speed by digit symbol substitution test (DSST), visuospatial functioning, memory and executive functioning (STROOP). In addition, a genetic risk score (GRS) for TL includin…

0301 basic medicineOncologycognitionNetherlands Twin Register (NTR)Psychometricsgenetic associationgenotypepolymerase chain reactionStatistics as TopicNeuropsychological Testsgenetic riskDISEASE3124 Neurology and psychiatryCohort Studies0302 clinical medicinesingle nucleotide polymorphismcognitive defectYOUNG-ADULTSgenetic variabilitytelomere lengthMedicineGWAScognitive performanceta515depth perceptionNetherlandsRISKlearningmedicine.diagnostic_testdigit symbol substitution testquantitative analysisDEMENTIAGenetic Carrier ScreeningadultarticleMini Mental State ExaminationCognitionta3142episodic memoryznf208 geneMiddle AgedTelomereapolipoprotein E4cohort analysisrtel1 genePsychiatry and Mental healthPROCESSING SPEEDacyp2 genefemaleancestry groupMENDELIAN RANDOMIZATIONOriginal ArticleClinical psychologymedicine.medical_specialtytert genePsychometricsMendelian randomization analysisgenetic risk scoreWhite People03 medical and health sciencesCellular and Molecular NeurosciencemaleInternal medicineMendelian randomizationpleiotropyJournal Article/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_HumansCognitive DysfunctionEffects of sleep deprivation on cognitive performancehumangeneBiological PsychiatryMETAANALYSISAgedterc geneStroop testMini–Mental State Examinationgenome-wide association studyIDENTIFICATIONPsykologi (exklusive tillämpad psykologi)business.industryMORTALITYobfc1 genemajor clinical studyConfidence intervalPsychology (excluding Applied Psychology)030104 developmental biologyexecutive functionDigit symbol substitution testnaf1 geneobservational studybusiness030217 neurology & neurosurgeryStroop effect
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Effect of dulaglutide on cognitive impairment in type 2 diabetes: an exploratory analysis of the REWIND trial

2020

Digital

AdultMalemedicine.medical_specialtyRecombinant Fusion ProteinsGlucagon-Like Peptides030209 endocrinology & metabolismType 2 diabetesPlacebolaw.invention03 medical and health sciences0302 clinical medicineDouble-Blind MethodRandomized controlled triallawInternal medicinemedicineHumansHypoglycemic AgentsCognitive DysfunctionRisk factorAgedbusiness.industryHazard ratioMontreal Cognitive AssessmentMiddle Agedmedicine.diseaseImmunoglobulin Fc FragmentsTreatment OutcomeDiabetes Mellitus Type 2Digit symbol substitution testFemaleDulaglutideNeurology (clinical)business030217 neurology & neurosurgerymedicine.drug
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Is processing speed a valid neurocognitive endophenotype in bipolar disorder? Evidence from a longitudinal, family study.

2021

[Background] Substantial evidence supports the existence of neurocognitive endophenotypes in bipolar disorder (BD), but very few longitudinal studies have included unaffected relatives. In a 5-year, follow-up, family study, we have recently suggested that deficits in manual motor speed and visual memory could be endophenotype candidates for BD. We aimed to explore whether this also applies to processing speed.

Longitudinal studyEndophenotypesBipolar disorderNeuropsychological TestsCognitionVisual memoryHumansMedicineLongitudinal StudiesBipolar disorderBiological Psychiatrybusiness.industryCognitionmedicine.diseaseFamily studyPsychiatry and Mental healthEndophenotypeMoodEndophenotypeDigit symbol substitution testLongitudinal studyCognition DisordersbusinessProcessing speedNeurocognitiveClinical psychology
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Costrutti locativi e non locativi con mettere

2013

Sentence (a) Ada mise Pio nel sacco is ambiguous: one of its meanings is literal (Ada put Pio in the sack), whereas the other is figurative (Ada fooled / outsmarted Pio). Such ambiguity is not present in sentence (b) Ada mise Pio in un sacco. On the surface, (b) differs from (a) only insofar as the indefinite article is employed, but conveys a literal meaning exclusively (Ada put Pio in a sack). The ambiguity of sentence (a) is derived from the existence of two constructions employing mettere. The prepositional phrase of one of them displays standard paradigmatic properties and conveys literal (i.e. locative) meaning, whereas the other has no locative value and is highly constrained (e.g. n…

non-verbal predication argument structure substitution test locative multi-word expressionsSettore L-LIN/01 - Glottologia E Linguistica
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